Important clinical notice: This tool is for informational purposes only and is based on cited scientific publications. It does not replace consultation with your specialist medical team. Any dietary intervention must be supervised by a gastroenterologist and/or registered dietitian.
Crohn's Disease Exclusion Diet
What is CDED?
The Crohn's Disease Exclusion Diet (CDED) is a whole-food dietary intervention designed to reduce luminal exposure to dietary components thought to adversely affect the gut microbiome and intestinal permeability. It was developed by Dr. Arie Levine and colleagues, and validated in a randomized controlled trial (RCT) published in Gastroenterology (2019).
[1]
Phase 1: Induction
Weeks 1–6. 50% of caloric intake from CDED foods, 50% from Partial Enteral Nutrition (PEN).
Open →Phase 2: Reintroduction
Weeks 7–12. Greater dietary variety. PEN is reduced to 25% of caloric intake.
Open →Phase 3: Maintenance
From week 13 onwards. The goal of this phase is to sustain long-term remission and improve the patient's quality of life. The diet is made more flexible by allowing a greater variety of foods, with controlled free meals introduced during the week, while maintaining enteral formula at 25% of energy requirements.
Open →Calculate a personalised Partial Enteral Nutrition plan for your patient.
Open IBDNutriCalc →Bibliographic References
- [1]
Levine A, Wine E, Assa A, et al. Crohn's Disease Exclusion Diet Plus Partial Enteral Nutrition Induces Sustained Remission in a Randomized Controlled Trial. Gastroenterology. 2019;157(2):440-450.e8. PMID: 31170412
- [2]
Sigall Boneh R, Sarbagili Shabat C, Yanai H, et al. Dietary Therapy with the Crohn's Disease Exclusion Diet is a Successful Strategy for Induction of Remission in Children and Adults Failing Biological Therapy. J Crohns Colitis. 2017;11(10):1205-1212. PMID: 28525622